Drug Notebook

FDA Alerts

    Administration Warnings
  • For IV use only.
  • Fatal if given intrathecally. (See Intrathecal Administration under Cautions.)
  • Extremely important to properly place IV needle or catheter before any vincristine is injected.
  • Leakage into surrounding tissues may cause considerable irritation.
  • Discontinue immediately if leakage occurs; administer remainder of the dose through another vein.
  • Local treatment of leakage area (e.g., with hyaluronidase injection, application of moderate heat) may help disperse vincristine and minimize discomfort and possibility of cellulitis.

    Limit to Qualified Personnel
  • For administration only by individuals experienced in the administration of vincristine.

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What is the most important information I should know about vincristine?

Vincristine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of vincristine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); nerve damage (burning, pricking, or tingling; loss of reflexes and difficulty in walking); severe nausea, vomiting, constipation, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with vincristine.

What is vincristine?

Vincristine is a cancer (antineoplastic) medication. Vincristine interferes with the growth of cancer cells and slows their growth and spread in the body.

Vincristine is used in the treatment of leukemia. Vincristine has also been used in the treatment of Hodgkin's lymphoma, non-Hodgkin's lymphoma, rhabdomyosarcoma, neuroblastoma, Wilms' tumor, and other types of cancer.

Vincristine may also be used for purposes other than those listed in this medication guide.

Who should not use vincristine?

Do not use vincristine without first talking to your doctor if you have

The use of vincristine may be dangerous if you have any of the conditions listed above.

Vincristine is in the FDA pregnancy category D. This means that vincristine is known to be harmful to an unborn baby. Do not use vincristine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with vincristine. It is not know whether vincristine passes into breast milk. Breast-feeding should be avoided during treatment with vincristine.

How should I use vincristine?

Vincristine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with vincristine depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Tell your doctor or nurse right away if you notice redness, pain or swelling at the place of injection or anywhere else on your skin.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with vincristine to monitor progress and side effects.

Your healthcare provider will store vincristine as directed by the manufacturer. If you are storing vincristine at home, follow the directions provided by your healthcare provider.

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