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What other drugs will affect sertraline?

Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with sertraline may cause you to bruise or bleed easily.

Before taking sertraline, tell your doctor if you are using any of the following medicines:

• tramadol (Ultram, Ultram ER, Ultracet);

• digitoxin (Crystodigin);

• phenytoin (Dilantin), valproate (Depacon, Depakene);

• lithium (Lithobid, Eskalith);

• a blood thinner such as warfarin (Coumadin);

• any other antidepressants such as amitriptyline (Elavil), citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), or paroxetine (Paxil);

• almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

• heart rhythm medication such as flecainide (Tambocor), propafenone (Rhythmol), and others.

If you are using any of these drugs, you may not be able to use sertraline, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect sertraline. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has additional information about sertraline written for health professionals that you may read.

What does my medication look like?

Sertraline is available with a prescription under the brand name Zoloft. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Zoloft 25 mg-capsule-shaped, green, film-coated, scored tablets

• Zoloft 50 mg--capsule-shaped, light-blue, film-coated, scored tablets

• Zoloft 100 mg--capsule-shaped, light-yellow, film-coated, scored tablets

• Zoloft Oral Concentrate 20 mg/mL-clear, colorless solution with a menthol scent

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.