• Basic Info
• Top Questions
• Clinical Info
• Interactions

What is the most important information I should know about procarbazine?

Procarbazine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of procarbazine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat); nervous system side effects (numbness, tingling, or confusion); sore in or around the mouth; and diarrhea. Talk to your doctor about the possible side effects from treatment with procarbazine.

Avoid alcohol, chocolate, and all of the foods listed in the "What should I avoid while taking procarbazine?" section of this leaflet. Foods high in tyramine can cause a severe reaction, including a severe headache, large pupils, neck stiffness, nausea, vomiting, sweating, irregular heartbeats, and chest pain. Call your doctor immediately if you experience any of the symptoms listed above.

Procarbazine may interact with many other medications, sometimes resulting in serious side effects. Do not take any other prescription or over-the-counter medicines, including herbal products, during treatment with procarbazine without first talking to your doctor.

What is procarbazine?

Procarbazine is a cancer (antineoplastic) medication. Procarbazine interferes with the growth of cancer cells and slows their growth and spread in the body.

Procarbazine is used to treat Hodgkin's Disease (a type of blood cancer).

Procarbazine may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking procarbazine?

Before taking procarbazine, tell your doctor if you have:

• kidney disease;
• liver disease;

• bone marrow problems; or

• glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.

You may not be able to take procarbazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Procarbazine is in the FDA pregnancy category D. This means that procarbazine is known to cause birth defects in an unborn baby. Procarbazine may also affect egg production in women and sperm production in men. Do not take procarbazine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with procarbazine. It is not known whether procarbazine passes into breast milk. Do not take procarbazine without first talking to your doctor if you are breast feeding a baby.

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