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What is the most important information I should know about perphenazine?

Call your doctor immediately if you have uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs. Use caution when driving, operating machinery, or performing other hazardous activities. Perphenazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking perphenazine. Do not mix the liquid form of this medication with coffee, cola, tea, grape, or apple juice.

What is perphenazine?

Perphenazine is in a class of drugs called phenothiazines. It works by changing the actions of chemicals in your brain.

Perphenazine is used to treat psychotic disorders, nausea, and vomiting.

Perphenazine may also be used for purposes other than those listed in this medication guide.

Who should not take perphenazine?

Before taking this medication, tell your doctor if you have

• a bone marrow disease,

• glaucoma,

• seizures,

• Parkinson's disease,

• an enlarged prostate or difficulty urinating,

• liver disease, or
• kidney disease.

You may not be able to take perphenazine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether perphenazine will harm an unborn baby. Do not take perphenazine without first talking to your doctor if you are pregnant. It is not known whether perphenazine passes into breast milk. Do not take perphenazine without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from perphenazine. You may require a lower dose of this medication.