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What is the most important information I should know about pemoline?

Pemoline was withdrawn from the U.S. market in 2005.

In rare cases, pemoline has caused severe liver damage resulting in death or liver transplant. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, itching, clay-colored stools, or dark urine. These symptoms may be early signs of liver damage. Before taking pemoline, you will be required to discuss with your doctor the risks and benefits of this medicine and to sign an informed consent stating that you understand these risks and benefits. Also, your doctor will need to monitor your liver function with blood tests before starting therapy with pemoline, and every two weeks thereafter.

Use caution when driving, operating machinery, or performing other hazardous activities. Pemoline may cause dizziness or impair your ability to concentrate. If you experience dizziness or impaired concentration, avoid these activities.

What is pemoline?

Pemoline was withdrawn from the U.S. market in 2005.

Pemoline stimulates the central nervous system (brain and nerves). The exact way that pemoline work is unknown.

Pemoline is used to treat attention deficit hyperactivity disorder (ADHD).

Pemoline may also be used for purposes other than those listed in this medication guide.

Who should not take pemoline?

Before taking this medication, tell your doctor if you have

• liver disease,
• kidney disease,

• seizures or epilepsy,

• Tourette's syndrome, or

• a history of drug or alcohol abuse.

You may not be able to take pemoline or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Pemoline is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take pemoline without first talking to your doctor if you are pregnant. It is also not known whether pemoline passes into breast milk. Do not take pemoline without first talking to your doctor if you are breast-feeding a baby. The safety and effectiveness of pemoline for use by children younger than 6 years of age have not been established.