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What is the most important information I should know about nitroprusside?

You should not receive this medication if you are allergic to nitroprusside, or if you have hereditary vision loss (Leber's disease), vision problems caused by smoking, or a history of blood clot in your brain.

Before receiving nitroprusside, tell your doctor if you have high blood pressure (hypertension), liver disease, anemia (a lack of red blood cells), a seizure disorder, or a history of head injury or brain tumor.

Seek emergency medical attention if you think you have received too much of this medicine.

Symptoms of a nitroprusside overdose may include nausea, vomiting, stomach pain, sweating, severe dizziness, headache, muscle twitching, fast or pounding heartbeat, restless feeling, and chest or back pain.

Tell your caregivers right away about any serious side effects such as breathing problems, tremors or chills, numbness or cold feeling in your hands or feet, easy bruising, unusual bleeding, muscle pain or weakness, confusion, feeling extremely light-headed, or fainting.

What is nitroprusside?

Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.

Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). Nitroprusside is also used to keep blood pressure low during a surgery.

Nitroprusside may also be used for purposes other than those listed in this medication guide.

What should I discuss with my health care provider before receiving nitroprusside?

You should not receive this medication if you are allergic to nitroprusside, or if you have:

• hereditary vision loss (Leber's disease);

• vision problems caused by smoking; or

• a history of blood clot in your brain.

Before receiving nitroprusside, tell your doctor if you are allergic to any drugs, or if you have:

• high blood pressure (hypertension);

• liver disease;

• anemia (a lack of red blood cells);

• epilepsy or other seizure disorder; or

• a history of head injury or brain tumor.

If you have any of these conditions, you may not be able to receive nitroprusside, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Nitroprusside may pass into breast milk and could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.