).
These drugs are no longer available in the U.S. but should also not be taken together with
nefazodone: astemizole (Hismanal), or terfenadine (Seldane).
There are many other medicines that can interact with nefazodone. Tell your doctor about all the prescription and over-the-counter medications you use.
This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not
start using a new medication without telling your doctor. Keep a list with you of all the
medicines you use and show this list to any doctor or other healthcare provider who treats you.
You may have thoughts about suicide when you first start taking an antidepressant,
especially if you are younger than 24 years old. Your doctor will need to check you at regular
visits for at least the first 12 weeks of treatment.
Call your doctor at once if you have any new or worsening symptoms such as: mood
or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable,
agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or
have thoughts about suicide or hurting yourself.
What is nefazodone?
Nefazodone is an antidepressant. It is used to treat depression, including major depressive
disorder.
Nefazodone is not chemically similar to other groups of antidepressants, such as selective
serotonin reuptake inhibitors or "SSRIs", tricyclic antidepressants, or monoamine oxidase
inhibitors or "MAOIs."
Nefazodone may also be used for other purposes not listed in this medication guide.
What should I discuss with my healthcare provider before taking nefazodone?
You should not take this medication if you are allergic to nefazodone or trazodone
(Desyrel), or if you have ever had liver problems caused by taking nefazodone.
Do not take nefazodone if you are using any of the following drugs:
-
carbamazepine (Tegretol);
-
cisapride (Propulsid);
-
pimozide (Orap);
-
an MAO inhibitor such as isocarboxazid (Marplan),
tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl,
Emsam); or
-
(these drugs are no longer available in the U.S.) astemizole
(Hismanal) or terfenadine (Seldane).
Serious and sometimes fatal reactions can occur when these
medicines are taken with nefazodone. You must wait at least 14 days after stopping an MAO
inhibitor before you can take nefazodone. You must wait 7 days after stopping nefazodone
before you can take an MAOI.
Before taking nefazodone, tell your doctor if you are allergic to any drugs, or if you have:
If you have any of these conditions, you may need a dose adjustment
or special tests to safely take nefazodone.
You may have thoughts about suicide while taking an antidepressant, especially if you are
younger than 24 years old. Tell your doctor if you have worsening depression or suicidal
thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or
symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of
treatment.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell
your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether nefazodone passes into breast milk or if it could harm a
nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a
baby.
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