Drug Notebook

FDA Alerts

Special Alerts:

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antipsychotics, http://www.fda.gov/cder/drug/InfoSheets/HCP/antipsychotics_conventional.htm and http://www.fda.gov/bbs/topics/NEWS/2008/NEW01851.html.

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loxapine
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(LOX a peen)

What is the most important information I should know about loxapine?

Call your doctor immediately if you experience uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs. Use caution when driving, operating machinery, or performing other hazardous activities. Loxapine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking loxapine.

Avoid becoming overheated during loxapine therapy. It is easier to become dangerously dehydrated while you are taking loxapine. Use caution in hot weather and during exercise.

What is loxapine?

Loxapine is an antipsychotic medication. It works by changing the actions of chemicals in your brain.

Loxapine is used to treat the symptoms of psychotic conditions, including hallucinations, delusions, and confusion.

Loxapine may also be used for purposes other than those listed in this medication guide.

Who should not take loxapine?

Before taking this medication, tell your doctor if you have

You may not be able to take loxapine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether loxapine will harm an unborn baby. Do not take loxapine without first talking to your doctor if you are pregnant or if you are planning a pregnancy. It is also not known whether loxapine passes into breast milk. Do not take loxapine if you are breast-feeding a baby without the approval of your doctor.
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