• Basic Info
• Top Questions
• Interactions

What is the most important information I should know about isoniazid/pyrazinamide/rifampin?

Take all of the isoniazid/pyrazinamide/rifampin that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Avoid alcohol while taking isoniazid/pyrazinamide/rifampin. Alcohol will increase the risk of damage to your liver during treatment with this medication.

Call your doctor immediately if you experience a fever, chills, a sore throat, muscle and bone pain, painful or swollen joints, a headache, excessive tiredness or weakness, numbness or tingling in your hands or feet, loss of appetite, nausea and vomiting, yellowing of your skin or eyes, darkening of your urine, unusual bleeding or bruising, a rash, or itching.

Take isoniazid/pyrazinamide/rifampin on an empty stomach 1 hour before or 2 hours after meals. This medication may decrease the effectiveness of birth control pills. Talk to your doctor about using another form of birth control during treatment.

What is isoniazid/pyrazinamide/rifampin?

Isoniazid, pyrazinamide, and rifampin are antibiotics. They prevent tuberculous bacteria from multiplying in your body.

Isoniazid, pyrazinamide, and rifampin are used together to treat tuberculosis (TB).

Isoniazid/pyrazinamide/rifampin may also be used for purposes other than those listed in this medication guide.

Who should not take isoniazid/pyrazinamide/rifampin?

Before taking this medication, tell your doctor if you have

• ever had an allergic reaction;

• kidney disease;

• liver disease;

• porphyria;

• gout; or

• diabetes mellitus.

You may not be able to take isoniazid/pyrazinamide/rifampin, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether isoniazid/pyrazinamide/rifampin will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether isoniazid/pyrazinamide/rifampin will harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.