Drug Notebook

FDA Alerts

    IGIV-associated Renal Dysfunction
  • Renal dysfunction, acute renal failure, osmotic nephrosis, and death reported in patients receiving IGIV. (See IGIV-associated Renal Effects under Cautions.)
  • Patients at increased risk of acute renal failure include those with any degree of preexisting renal insufficiency, diabetes mellitus, volume depletion, sepsis, or paraproteinemia; those receiving concomitant nephrotoxic drugs; and/or those >65 years of age.
  • Administer IGIV at the minimum concentration available and at the minimum practicable infusion rate in these patients.

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What is the most important information I should know about immune globulin?

Immune globulin can be harmful to the kidneys, and these effects are increased when immune globulin is used together with other medicines that can harm the kidneys. Before using immune globulin, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.

Before you use immune globulin intravenous, tell your doctor if you have kidney disease, diabetes (especially if you use insulin), a history of stroke or blood clot, heart disease, high blood pressure, a condition called paraproteinemia, or if you are over 65 years old.

To be sure this medication is helping your condition and is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be checked. Do not miss any scheduled appointments.

Using immune globulin can cause you to have unusual results with certain blood glucose tests. Tell any doctor who treats you that you are using immune globulin.

Immune globulin is made from human plasma (part of the blood) and may contain viruses and other infectious agents that can cause disease. Although immune globulin is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

What is immune globulin?

Immune globulin intravenous is a sterilized solution made from human plasma. It contains the antibodies to help your body protect itself against infection from various diseases.

Immune globulin is used to treat primary immune deficiency, and to reduce the risk of infection in individuals with poorly functioning immune systems such as those with chronic lymphocytic leukemia (CLL). IGIV is also used to increase platelets (blood clotting cells) in people with idiopathic thrombocytopenic purpura (ITP) and to prevent aneurysm caused by a weakening of the main artery in the heart associated with Kawasaki syndrome.

Immune globulin may also be used for other purposes not listed in this medication guide.

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