Drug Notebook

FDA Alerts

  • Administer only under supervision of qualified clinicians experienced in the use of cancer chemotherapeutic agents.
  • Hemorrhagic cystitis may occur and may require discontinuance of therapy (See Bladder Toxicity under Cautions).
  • Severe neurotoxicity (e.g., confusion, coma) may occur and may require discontinuance of therapy (See Nervous System Effects under Cautions).
  • Severe myelosuppression reported (See Hematologic Effects under Cautions).

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ifosfamide
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(eye FOS fah mide)

What is the most important information I should know about ifosfamide?

Ifosfamide should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of ifosfamide including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat); urinary problems (blood in the urine, difficulty urinating, or increased frequency of urination); neurologic problems (drowsiness, confusion, hallucinations, and coma); and others. Talk to your doctor about the possible side effects from treatment with ifosfamide.

What is ifosfamide?

Ifosfamide is a cancer (antineoplastic) medication. Ifosfamide interferes with the growth of cancer cells and slows their growth and spread in the body.

Ifosfamide is used to treat testicular cancer.

Ifosfamide may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking ifosfamide?

Before taking ifosfamide, tell your doctor if you have:

You may not be able to take ifosfamide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Ifosfamide is in the FDA pregnancy category D. This means that ifosfamide is known to cause birth defects in an unborn baby. Do not take ifosfamide without first talking to your doctor if you are pregnant or could become pregnant during treatment. Ifosfamide passes into breast milk and may harm a nursing infant. Do not take ifosfamide without first talking to your doctor if you are breast feeding a baby.
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