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What is the most important information I should know about glyburide?

Treatment with glyburide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with glyburide.

Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar.

Follow diet, medication, and exercise routines closely. Changing any of them can affect blood sugar levels.

Do not change your dose of glyburide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with diabetes treatment.

What is glyburide?

Glyburide is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels.

Glyburide is used to treat type 2 diabetes along with diet, exercise, and insulin therapy, if necessary.

Glyburide may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking glyburide?

Before taking glyburide, tell your doctor if you

• have kidney disease;
• have liver disease;

• have thyroid disease;

• have type 1 diabetes;

• have a serious infection, illness, or injury; or

• need surgery.

You may not be able to take glyburide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Patients 65 years of age and older may have a stronger reaction to glyburide and may require a reduced dose.

Glyburide is in the FDA pregnancy category C. This means that it is not known whether glyburide will be harmful to an unborn baby. Insulin is usually the drug of choice for controlling diabetes during pregnancy. Do not take glyburide without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether glyburide passes into breast milk. Do not take glyburide without first talking to your doctor if you are breast-feeding a baby.