Drug Notebook

FDA Alerts

  • The major toxicity is renal impairment. It is imperative that adequate hydration be maintained, serum creatinine be monitored frequently, and dosage adjusted for changes in renal function. (See Hydration under Dosage and Administration.)
  • Seizures related to alterations in plasma minerals and electrolytes may occur. Carefully monitor for such changes and their potential sequelae. Mineral and electrolyte supplementation may be required.
  • The only FDA-approved indications are treatment of cytomegalovirus (CMV) retinitis in HIV-infected patients or treatment of mucocutaneous acyclovir-resistant HSV infections in immunocompromised patients.

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foscarnet
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(fos KAR net)

What is the most important information I should know about foscarnet?

Foscarnet is not a cure for CMV, and the virus may progress during or after treatment.

Before using foscarnet, tell your doctor if you have kidney disease, a seizure disorder, heart disease, a nerve disorder, or an electrolyte imbalance such as low calcium, potassium, or magnesium.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested, and you may also need regular eye exams. Do not miss any scheduled visits to your doctor.

Stop using foscarnet and call your doctor at once if you urinate less than usual or not at all, or if you have numbness or tingling around your mouth, uncontrolled muscle movements, or pain or burning when you urinate. There are many other medicines that can cause kidney damage or lower calcium levels and should not be used together with foscarnet. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

What is foscarnet?

Foscarnet is an antiviral medication that prevents certain virus cells from multiplying in your body.

Foscarnet is used to treat cytomegalovirus (CMV) retinitis in people with AIDS. Foscarnet is not a cure for CMV, and the virus may progress during or after treatment.

Foscarnet is also used to treat herpes simplex virus (HSV) in people with a weak immune system. Foscarnet is usually given for HSV after other antiviral medications have been tried without successful treatment.

Foscarnet may also be used for purposes other than those listed in this medication guide.

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