Drug Notebook

FDA Alerts

Special Alerts:

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antipsychotics, http://www.fda.gov/cder/drug/InfoSheets/HCP/antipsychotics_conventional.htm and http://www.fda.gov/bbs/topics/NEWS/2008/NEW01851.html.

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fluphenazine
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(floo FEN a zeen)

What is the most important information I should know about fluphenazine?

Call your doctor immediately if you have uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs. Use caution when driving, operating machinery, or performing other hazardous activities. Fluphenazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking fluphenazine. Do not mix the liquid form of this medication with coffee, cola, tea, grape, or apple juice.

What is fluphenazine?

Fluphenazine is in a class of drugs called phenothiazines. It works by changing the actions of chemicals in the brain.

Fluphenazine is used to treat psychotic disorders.

Fluphenazine may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking fluphenazine?

Before taking fluphenazine, tell your doctor if you have

You may not be able to take fluphenazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether fluphenazine will be harmful to an unborn baby. Do not take fluphenazine without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether fluphenazine passes into breast milk. Do not take fluphenazine without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from fluphenazine. Your doctor may prescribe a lower dose of this medication.
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