Drug Notebook

FDA Alerts

  • Only for administration by, or under the supervision of, a clinician experienced in cancer chemotherapy and the use of antimetabolites.
  • Severe toxic reactions are possible; hospitalize patients, at least during initial course of therapy.

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fluorouracil
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(flore oh YER a sill)

What is the most important information I should know about fluorouracil?

Fluorouracil should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of fluorouracil including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection); sores in the mouth or throat; severe vomiting or diarrhea; and others. Talk to your doctor about the possible side effects from treatment with fluorouracil.

What is fluorouracil?

Fluorouracil is a cancer (antineoplastic) medication. Fluorouracil interferes with the growth of cancer cells and slows their growth and spread in the body.

Fluorouracil is used in the treatment of colon, rectum, breast, stomach, and pancreas cancer.

Fluorouracil may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking fluorouracil?

Do not use fluorouracil without first talking to your doctor if you have

The use of fluorouracil may be dangerous if you have any of the conditions listed above.

Fluorouracil is in the FDA pregnancy category D. This means that it is known to be harmful to an unborn baby. Do not use fluorouracil without first talking to your doctor if you are pregnant or could become pregnant during treatment. Discuss with your doctor the appropriate use of birth control during treatment with fluorouracil. It is not known whether fluorouracil passes into breast milk. Do not take fluorouracil without first talking to your doctor if you are breast feeding a baby.
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