What is the most important information I should know about estradiol vaginal (local)?
Some estradiol products placed directly into the vagina are used for "local" treatment of
vaginal menopause symtoms involving the secretions and surrounding tissues of the vagina.
Other vaginal estradiol products are used for treating menopause symptoms affecting the vagina
as well as other parts of the body (such as hot flashes). This type of vaginal estradiol has
"systemic" effects, meaning that it can affect parts of the body other than where the medicine is
placed or applied.
The information in this leaflet is specific to estradiol vaginal products that are used for
local treatment of symptoms.
Do not use this medication if you have any of the following conditions: a history of
stroke or
blood clot, circulation problems, a hormone-related cancer such as breast or
uterine
cancer, or abnormal
vaginal bleeding.
This medication can cause birth defects in an unborn baby. Do not use
if you are pregnant. Use an effective form of birth control, and tell your doctor if you
become pregnant during treatment.
Estradiol increases your risk of developing endometrial hyperplasia, a condition that may
lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your
uterus has not been removed, your doctor may prescribe a progestin for you to take while you are
using estradiol vaginal.
Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or
stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your
doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether
you should continue this treatment.
Have regular physical exams and self-examine your breasts for lumps on a monthly basis
while using estradiol.
What is estradiol vaginal (local)?
Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the
body.
Estradiol vaginal (local) is used to treat certain symptoms of menopause such as dryness,
burning, and itching of the vaginal area. Estradiol vaginal also reduces urgency or irritation of
urination.
Estradiol vaginal (local) may also be used for purposes other than those listed in this
medication guide.
Print
Email
Save
Drug Info Tools
Medicare's drug plans are subsidized by the US federal government and offered through insurers.
