What is the most important information I should know about estradiol?
Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to
cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol lowers
the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may
prescribe a progestin for you to take together while using estradiol. Visit your doctor regularly and
report any unusual vaginal bleeding right away.
Treatment with estradiol long-term may increase the risk of stroke. Because of this risk, you
should contact your doctor or healthcare provider to discuss your individual risks and benefits before
taking estradiol long-term. You should also talk to your doctor or healthcare provider on a regular basis
(for example, every 3-6 months) about whether you should continue this treatment.
Have yearly physical exams and examine your breasts for lumps on a monthly basis while using
estradiol.
Do not use this medication if you are
pregnant.
The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction,
stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women
(50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with
medroxyprogesterone acetate.
The Women's Health Initiative Memory Study (WHIMS) found that postmenopausal women
65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone
acetate had an increased risk of developing dementia. It is unknown whether this finding applies to
younger postmenopausal women or to women using estrogen only therapy.
What is estradiol?
Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the
body. Estradiol vaginal products release estrogen that is absorbed directly through the skin of the
vaginal wall.
Estradiol topical is used to treat certain symptoms of menopause such as dryness, burning, and
itching of the vaginal area and urgency or irritation with urination.
Estradiol may also be used for purposes other than those listed in this medication guide.
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