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Drug Notebook

Generic Name: estradiol

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Oestrogel Pump-Pack, Valergen, Dep Gynogen, Dioval 40, Estradiol Valerate, OESTRODOSE, Sandrena, MENOREST, Dermestril - Septem, PROVAMES, Vivelle-Dot, Estradiol Patch, FEMSEPT, Dermestril, Gynogen LA 20, Estradot, ESTRADERM TTS, ESTRADIOL G GAM, THAISSEPT, Estraderm TTS, ESTRAPATCH, DERMESTRIL, Depo-Estradiol, CLIMARA, Progynova, FemTab, Progynova TS, OESTROGEL, Femring, Elleste Solo, Depogen, FemSeven Sequi Phase I, Estragyn LA 5, Menaval-20, Delestrogen, Climara, Fematrix, Bedol, Estradiol Benzoate, Nuvelle TS Phase I, VIVELLEDOT, SYSTEN, Estraderm MX, Dioval XX, Climodien, Estra-C, Estraderm, Organon Oestradiol, Evorel, Primogyn Depot, PROGYNOVA, Oestradiol Implants, Gynodiol, Aerodiol, Estro-Cyp, Estrofem, OROMONE, Zumenon, Esclim, Femtrace, ESTROFEM, Alora, Estra-V 40, Duragen, Menostar, FemSeven, Fempatch, Estradiol Cypionate, ESTREVA, Estro-Span 40, Climaval, Medidiol 10, Oestradiol, AERODIOL, Dura-Estrin, DELIDOSE, Vivelle, Clinagen LA 40, Femtran, Adgyn Estro, Menorest Patch, Estrace, Oesclim
An estrogen - used during/for Oophorectomy, treats Osteoporosis, Hypoestrogenism, Atrophic Urethriti... more
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FDA Alerts

  • Estrogens increase the risk of endometrial cancer in postmenopausal women. (See Endometrial Cancer under Cautions.)
  • Do not use estrogens with or without progestins for prevention of cardiovascular disease (see Cardiovascular Risk Reduction under Uses and Cardiovascular Disorders under Cautions) or dementia (see Alzheimer's Disease under Uses).
  • The Women’s Health Initiative (WHI) study of estrogen alone reported increased risks of stroke and DVT in postmenopausal women receiving approximately 7 years of therapy with conjugated estrogens 0.625 mg daily.
  • The WHI study of estrogen plus progestin reported increased risks of MI, stroke, invasive breast cancer, pulmonary embolism, and DVT in postmenopausal women receiving >5 years of therapy with conjugated estrogens 0.625 mg in conjunction with medroxyprogesterone acetate 2.5 mg daily.
  • The WHI Memory Study (WHIMS) reported increased risk of developing probable dementia in postmenopausal women ≥65 years of age receiving long-term therapy (4–5 years) with conjugated estrogens in conjunction with medroxyprogesterone acetate or conjugated estrogen alone. Not known whether this finding also applies to younger postmenopausal women.
  • Other dosages of conjugated estrogens with medroxyprogesterone and other combinations or dosage forms of estrogens with progestin not studied in WHI trials; in absence of comparable data, assume risks are similar.
  • Prescribe estrogens (with or without progestins) at the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman.

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What is the most important information I should know about estradiol vaginal (systemic)?

Some estradiol products placed directly into the vagina are used for "local" treatment of vaginal menopause symtoms involving the secretions and surrounding tissues of the vagina. Other vaginal estradiol products are used for treating menopause symptoms affecting the vagina as well as other parts of the body (such as hot flashes). This type of vaginal estradiol has "systemic" effects, meaning that it can affect parts of the body other than where the medicine is placed or applied.

The information in this leaflet is specific to estradiol vaginal products that are used for systemic treatment of symptoms.

Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding. This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol vaginal.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol.

What is estradiol vaginal (systemic)?

Estradiol is a form of estrogen. Estrogen is a female sex hormone necessary for many processes in the body.

Estradiol vaginal (systemic) is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.

Estradiol vaginal (systemic) may also be used for purposes other than those listed in this medication guide.

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Centers
·As a Drug
Dysfunctional Uterine Bleeding (DUB)
Menopause
Osteoporosis
Postmenopausal Atrophic Vaginitis
Postmenopausal Bleeding
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