Drug Notebook

FDA Alerts

    Spinal/Epidural Hematoma Risk
  • Epidural or spinal hematomas and neurologic injury, including long-term or permanent paralysis, associated with concurrent use of low molecular weight heparins or heparinoids and neuraxial (spinal/epidural) anesthesia or spinal puncture.
  • Risk increased by use of indwelling epidural catheters for administration of analgesia or by concomitant use of drugs affecting hemostasis (e.g., NSAIAs, platelet inhibitors, other anticoagulants).
  • Risk also increased by traumatic or repeated epidural or spinal puncture.
  • Monitor frequently for signs and symptoms of neurological impairment and treat urgently if neurologic compromise noted.
  • Consider potential benefits versus risks of spinal or epidural anesthesia or spinal puncture in patients receiving or being considered for thromboprophylaxis with anticoagulants. (See Hematologic Effects and see Neurologic Effects under Cautions.)

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enoxaparin
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(ee nox AP a rin)

What is the most important information I should know about enoxaparin?

You should not receive this medication if you are allergic to enoxaparin, heparin, or pork products, or if you have any type of major bleeding or a very low blood platelet count.

Before receiving enoxaparin, tell your doctor if you are allergic to any drugs, or if you have kidney or liver disease, a heart infection, any bleeding or clotting disorder, high blood pressure, diabetes, a stomach ulcer, an artificial heart valve, or a history of stroke or recent brain or spine surgery.

To be sure this medication is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with enoxaparin. Do not miss any scheduled appointments.

You will most likely be treated with other medications such as aspirin or warfarin (Coumadin). To best treat your condition, use all of your medications as directed by your doctor. During your treatment with enoxaparin, do not use any other medications unless your doctor tells you to.

If you need to have any type of surgery or dental work, tell the surgeon or dentist ahead of time that you are using enoxaparin. You may need to stop using the medicine for a short time, especially if you will be receiving spinal or epidural anesthesia (also called spinal block). This type of anesthesia may increase the risk of paralysis in people who are also using enoxaparin.

What is enoxaparin?

Enoxaparin is a blood thinner, also called anticoagulant (an-tye-koe-AG-yoo-lant). Enoxaparin prevents the formation of blood clots.

Enoxaparin is used to prevent blood clots that are sometimes called deep vein thrombosis (DVT), which can lead to blood clots in the lungs. A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness. DVT sometimes occurs suddenly for other reasons.

Enoxaparin is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attacks called non-Q-wave myocardial infarction or ST-segment elevation myocardial infarction.

Enoxaparin may also be used for other purposes not listed in this medication guide.

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