This medication can cause birth defects in an unborn baby. Do not use
if you are pregnant. Use an effective form of birth control, and tell your doctor if you
become pregnant during treatment.
Drospirenone may raise potassium levels in your blood. Other medical conditions
can also affect potassium levels. Before using drospirenone and estradiol, tell your doctor about
all of your current and past medical conditions, and about all the medicines you use.
Stop using this medication and call your doctor at once if you feel short of breath,
have sudden numbness or weakness on one side of the body, sudden headache, confusion, or
problems with vision, speech, or balance.
Call your doctor right away if you have a breast lump, unusual vaginal bleeding, or
jaundice (yellowing of the skin or eyes).
What is drospirenone and estradiol?
Drospirenone is a female hormone that helps regulate ovulation and menstruation.
Estradiol is a female hormone involved in development and maintenance of the female
reproductive system.
Drospirenone and estradiol is used to treat the symptoms of menopause such as hot
flashes or vaginal changes (itching, burning, dryness, urination problems). It is also used to
prevent thinning of the bones (osteoporosis).
Drospirenone and estradiol may also be used for purposes other than those listed in this
medication guide.
What should I discuss with my doctor before taking drospirenone and estradiol?
Drospirenone may raise potassium levels in your blood. Other medical conditions
can also affect potassium levels. Before using drospirenone and estradiol, tell your doctor if you
have any of the following:
Certain medicines can also affect potassium levels. Tell your
doctor if you use any of the following drugs:
-
heparin;
-
aspirin or other NSAIDs (non-steroidal anti-inflammatory
drugs) such as celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Motrin, Advil),
indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene);
-
a diuretic ("water pill") such as spironolactone
(Aldactone), triamterene (Dyrenium, Dyazide, Maxzide), amiloride (Midamor), or eplerenone
(Inspra);
-
a potassium supplement such as Klor-Con, K-Dur, K-Tab;
-
an ACE inhibitor such as benazepril (Lotensin), lisinopril
(Prinivil, Zestril), enalapril (Vasotec); or
-
blood pressure medicine such as candesartan (Atacand),
losartan (Cozaar), telmisartan (Micardis).
If you have any of the following conditions, you may not be able to use
drospirenone and estradiol, or you may need a dosage adjustment or special tests during
treatment:
FDA pregnancy category X. This medication can cause birth
defects. Do not use this medication if you are pregnant. Tell your doctor
right away if you become pregnant during treatment.
Drospirenone and estradiol may affect breast milk. Do not take drospirenone and
estradiol without telling your doctor if you are breast-feeding a baby.
Estradiol may increase your risk of developing a condition that may lead to uterine cancer.
Taking the combination of drospirenone and estradiol may reduce this risk. Talk with your
doctor about your individual situation, and report any unusual vaginal bleeding right away.
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