Drug Notebook

FDA Alerts

    Mortality
  • Excessive mortality or nonfatal cardiac arrest rate (7.7%) in encainide- or flecainide-treated patients with asymptomatic non-life-threatening ventricular arrhythmias (with MI history >6 days but <2 years) in NHLBI's long-term CAST study relative to placebo. (See Mortality under Cautions.)
  • Applicability of CAST findings to other populations (e.g., those without recent MI) uncertain.
  • Because of disopyramide's proarrhythmic properties and lack of evidence of improved survival for any antiarrhythmic drug, reserve disopyramide for life-threatening ventricular arrhythmias.

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disopyramide
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(dye soe PEER a mide)

What is the most important information I should know about disopyramide?

Do not skip doses or change your dosing schedule without talking to your doctor. Changing your schedule could make your condition much worse. Use caution when driving, operating machinery, or performing other hazardous activities. Disopyramide may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. Do not crush, chew, or break any controlled-release (CR) forms of disopyramide. Swallow them whole. They are specially formulated to release slowly in your body.

What is disopyramide?

Disopyramide affects the way that your heart beats.

Disopyramide is used to treat seriously irregular heartbeat patterns.

Disopyramide may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking disopyramide?

Before taking disopyramide, tell your doctor if you have

You may not be able to take disopyramide, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Disopyramide is in the FDA pregnancy category C. This means that it is not known whether disopyramide will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Disopyramide passes into breast milk. It is not known whether disopyramide will affect a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take disopyramide?

Take disopyramide exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, chew, or break any controlled-release (CR) forms of disopyramide. Swallow them whole. They are specially formulated to release slowly in your body. Do not skip doses or change your dosing schedule without talking to your doctor. Changing your schedule could make your condition much worse. Store disopyramide at room temperature away from moisture and heat.
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