Drug Notebook

FDA Alerts

  • Cigarette smoking during oral contraceptive use increases the risk of serious adverse cardiovascular effects. This risk increases with age and with heavy smoking (≥15 cigarettes daily) and is markedly greater in women >35 years of age. Women who use oral contraceptives should be strongly advised not to smoke.

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desogestrel-ethinyl estradiol
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(EH thih nill ess tra DYE ole and des oh JESS trel)

What is the most important information I should know about ethinyl estradiol and desogestrel?

Do not use birth control pills if you are pregnant or if you have recently had a baby. Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems (especially if caused by diabetes), a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, liver disease or liver cancer, severe high blood pressure, migraine headaches, a heart valve disorder, or a history of jaundice caused by birth control pills.

You may need to use back-up birth control, such as condoms or a spermicide, when you first start using this medication. Follow your doctor's instructions.

Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you smoke and are older than 35.

Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all the prescription and over-the-counter medications you use, including vitamins, minerals and herbal products. Do not start using a new medication without telling your doctor.

What is ethinyl estradiol and desogestrel?

Ethinyl estradiol and desogestrel contains a combination of female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Ethinyl estradiol and desogestrel are used as contraception to prevent pregnancy.

Ethinyl estradiol and desogestrel may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking ethinyl estradiol and desogestrel?

This medication can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills (6 weeks if you are breast-feeding). Do not use this medication if you have:
  • a history of a stroke or blood clot;

  • circulation problems (especially if caused by diabetes);

  • a hormone-related cancer such as breast or uterine cancer;

  • abnormal vaginal bleeding;

  • liver disease or liver cancer;

  • severe high blood pressure;

  • severe migraine headaches;

  • a heart valve disorder; or

  • a history of jaundice caused by birth control pills.

Before using this medication, tell your doctor if you have any of the following conditions. You may need a dosage adjustment or special tests to safely take birth control pills.

The hormones in birth control pills can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.
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