Drug Notebook

FDA Alerts

    Dilution Warning
  • Concentrate for epidural injection must be diluted prior to administration.
    Obstetric, Postpartum, and Perioperative Pain
  • Not recommended for obstetric, postpartum, or perioperative pain management.
  • Risk of hemodynamic instability, especially hypotension and bradycardia, from epidural use may be unacceptable in these patients.
  • Rarely, potential benefits may outweigh possible risks in obstetric, postpartum, or perioperative patients.

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clonidine
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(KLOE ni deen)

What is the most important information I should know about clonidine?

Do not stop taking clonidine suddenly. This could cause severely high blood pressure, nervousness, and anxiety. Use caution when driving, operating machinery, or performing other hazardous activities. Clonidine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. You may become dizzy while taking clonidine and you may fall and injure yourself if you get up quickly.

Do not use alcohol, antihistamines, prescription pain relievers, sleeping pills, and other drugs that may cause drowsiness or dizziness except under the supervision of your doctor.

What is clonidine?

Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax (widen) and your heart to beat more slowly and easily.

Clonidine is used to treat hypertension (high blood pressure).

Although not approved by the FDA for these purposes, clonidine has also been used to relieve alcohol withdrawal, as an aid in methadone and opiate detoxification, as an aid in quitting smoking, to treat diabetic diarrhea, to treat Tourette's Syndrome, to reduce menopausal flushing, to treat postherpetic neuralgia, to treat ulcerative colitis, and to diagnose pheochromocytoma.

Clonidine may also be used for purposes other than those listed in this medication guide.

Who should not take clonidine?

Before taking this medication, tell your doctor if you

You may need a lower dose or special monitoring during treatment with clonidine if you have any of the conditions listed above.

Clonidine is in the FDA pregnancy category C. This means that it is not known whether clonidine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Clonidine passes into breast milk. It is not known whether clonidine will harm a nursing infant. Do not take clonidine without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from clonidine therapy. You may require a lower dose.
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