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Generic Name: clindamycin

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A lincomycin derivative - treats Skin or Soft Tissue Infection, Bacteremia, Bacterial Infection, Tox... more

FDA Alerts

Diarrhea and Colitis

Clostridium difficile-associated diarrhea and colitis (CDAD; also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) has been reported with nearly all anti-infectives, including clindamycin, and may range in severity from mild to life-threatening. Anti-infectives alter normal flora of the colon and may permit overgrowth of clostridia; a toxin produced by C. difficile is one primary cause of antibiotic-associated colitis.
It is important to consider a diagnosis of CDAD in patients who develop diarrhea subsequent to clindamycin treatment. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks after cessation of clindamycin therapy.
After a diagnosis of CDAD has been established, initiate therapeutic measures.

Mild cases usually respond to drug discontinuation alone.

In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an anti-infective clinically effective against CDAD. (See Superinfection/Clostridium difficile-associated Diarrhea and Colitis under Cautions.)
Because clindamycin has been associated with severe colitis (potentially fatal), it should be reserved for treatment of serious infections when less toxic anti-infectives are inappropriate.
Do not use for nonbacterial infections.

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Cleocin HCl
CLEOCIN 300 mg / CLEOCIN 300 mg 300 mg	CLEOCIN 150MG / CLEOCIN 150MG 150 mg
Clindamycin Hydrochloride
RX693 RX693 / RX693 RX693 300 mg	G 150 mg / 3328 150 mg	cor 153 cor 153 / cor 153 cor 153 150 mg	93 3171 / 93 3171 150 mg
DAN 5708 / DAN 5708 150 mg	cor 154 cor 154 / cor 154 cor 154 300 mg	DAN 3120 / DAN 3120 300 mg

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(klin da MYE sin)

How should I take clindamycin?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medicine with a full glass of water to keep it from irritating your throat. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. clindamycin will not treat a viral infection such as the common cold or flu.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using clindamycin. You may need to stop using the medicine for a short time.

Store clindamycin at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a clindamycin overdose may include depression, changes in behavior, or seizure (convulsions).

What should I avoid while taking clindamycin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

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