Drug Notebook

FDA Alerts

    Diarrhea and Colitis
  • Clostridium difficile-associated diarrhea and colitis (CDAD; also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) has been reported with nearly all anti-infectives, including clindamycin, and may range in severity from mild to life-threatening. Anti-infectives alter normal flora of the colon and may permit overgrowth of clostridia; a toxin produced by C. difficile is one primary cause of antibiotic-associated colitis.
  • It is important to consider a diagnosis of CDAD in patients who develop diarrhea subsequent to clindamycin treatment. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks after cessation of clindamycin therapy.
  • After a diagnosis of CDAD has been established, initiate therapeutic measures.

    Mild cases usually respond to drug discontinuation alone.

    In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an anti-infective clinically effective against CDAD. (See Superinfection/Clostridium difficile-associated Diarrhea and Colitis under Cautions.)

  • Because clindamycin has been associated with severe colitis (potentially fatal), it should be reserved for treatment of serious infections when less toxic anti-infectives are inappropriate.
  • Do not use for nonbacterial infections.

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clindamycin
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(klin da MYE sin)

What is the most important information I should know about clindamycin?

Do not use this medication if you are allergic to clindamycin or lincomycin (Bactramycin, L-Mycin, Lincocin)

Do not take clindamycin together with erythromycin (E-Mycin, E.E.S., Eryc, Ery-Tab, Robimycin, and others).

Before using clindamycin, tell your doctor if you have kidney disease, liver disease, an intestinal disorder such as colitis or Crohn's disease, or a history of asthma, eczema, or allergic skin reaction.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Clindamycin will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using clindamycin. You may need to stop using the medicine for a short time.

What is clindamycin?

Clindamycin is an antibiotic that fights bacteria in the body.

Clindamycin is used to treat serious infections caused by bacteria.

Clindamycin may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking clindamycin?

Do not use this medication if you are:
  • allergic to clindamycin or lincomycin (Bactramycin, L-Mycin, Lincocin); or

  • if you are also taking erythromycin (E-Mycin, E.E.S., Eryc, Ery-Tab, Robimycin, and others).

Before using clindamycin, tell your doctor if you are allergic to any drugs, or if you have:

  • colitis, Crohn's disease, or other intestinal disorder;

  • kidney disease;

  • liver disease; or

  • a history of asthma, eczema, or allergic skin reaction.

If you have any of these conditions, you may not be able to use clindamycin, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Clindamycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
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