What is the most important information I should know about cisapride?
Do not take
cisapride if you have
heart disease or hardening of the arteries;
heart failure; an
irregular heartbeat or a history of irregular heartbeats; a history of prolonged QT intervals; a
family
history of congenital
long QT syndrome; a slow heart rate that is considered a medical condition; a
structural heart defect; heart block or other conduction disturbances;
severe dehydration (loss of
water),
vomiting,
malnutrition, an
eating disorder; or
kidney failure. These conditions may increase the
risk of irregular heartbeats,
heart attack, and death while taking cisapride.
Do not take cisapride with any of the following drugs:
antibiotics such as
clarithromycin
(Biaxin),
erythromycin (Ery-Tab, E.E.S.,
E-Mycin, others),
troleandomycin (TAO), and
sparfloxacin
(Zagam);
antidepressants such as
amitriptyline (Elavil),
maprotiline (Ludiomil), and
nefazodone
(Serzone);
antifungal medications such as
fluconazole (Diflucan),
itraconazole (Sporanox), and
ketoconazole (Nizoral); phenothiazines such as
prochlorperazine (Compazine, others) and
promethazine (Phenergan, others);
antihistamines such as
astemizole (Hismanal);
blood pressure
medications such as
bepridil (Vascor); heart medications such as
procainamide (Procan SR,
Procanbid,
Pronestyl) and
quinidine (Quinidex, Quinaglute); and
HIV medications such as
indinavir (Crixivan) and
ritonavir (Norvir). Taken with any of these drugs, cisapride may cause irregular heartbeats that could
lead to death. This is not a complete list of drugs that may interact with cisapride and cause heart
problems. Talk to your doctor or
pharmacist before taking any other medications.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking
cisapride.
Use other medications cautiously during treatment with cisapride to avoid harming yourself
or others. Excessive drowsiness may result if
benzodiazepines such as
alprazolam (Xanax),
diazepam
(Valium),
chlordiazepoxide (Librium), and
temazepam (Restoril) are taken during treatment with
cisapride.
Do not consume grapefruit or grapefruit juice while taking cisapride. Grapefruit products
may increase amount of cisapride available in your body, which could lead to dangerous side effects.
What is cisapride?
Cisapride increases the rate at which your esophagus, stomach, and intestines move during
digestion. It also increases the rate at which your stomach empties into your intestines and increases the
strength of your lower esophageal sphincter (the muscle between your stomach and your esophagus).
Cisapride is used to treat gastric reflux (the regurgitation of stomach acid into the esophagus),
which is usually experienced as heartburn.
Cisapride may also be used for purposes other than those listed in this medication guide.
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