Drug Notebook

FDA Alerts

Special Alerts:

[Posted 06/16/2008] FDA notified healthcare professionals that both conventional and atypical antipsychotics are associated with an increased risk of mortality in elderly patients treated for dementia-related psychosis. In April 2005, FDA notified healthcare professionals that patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death. Since issuing that notification, FDA has reviewed additional information that indicates the risk is also associated with conventional antipsychotics. Antipsychotics are not indicated for the treatment of dementia-related psychosis. The prescribing information for all antipsychotic drugs will now include the same information about this risk in a BOXED WARNING and the WARNINGS section. For more information visit the FDA website at: http://www.fda.gov/medwatch/safety/2008/safety08.htm#Antipsychotics, http://www.fda.gov/cder/drug/InfoSheets/HCP/antipsychotics_conventional.htm and http://www.fda.gov/bbs/topics/NEWS/2008/NEW01851.html.

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chlorproMAZINE
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(klor PROE ma zeen)

What is the most important information I should know about chlorpromazine?

Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use this medication if you are allergic to chlorpromazine, or if you are also using large amounts of alcohol or medicines that make you sleepy.

Before you take chlorpromazine, tell your doctor if you have liver or kidney disease, heart disease or high blood pressure, glaucoma, a breathing disorder, any type of cancer, an enlarged prostate, blockage in your intestines, seizures, a brain tumor, or Parkinson's disease.

Tell your doctor if you will be exposed to extreme heat or to insecticide poisons while you are taking chlorpromazine.

Chlorpromazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. It can increase some of the side effects of chlorpromazine. Avoid exposure to sunlight, sunlamps, or tanning beds. Chlorpromazine can make your skin more sensitive to sunlight, and a sunburn may result.

What is chlorpromazine?

Chlorpromazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-zeens). It works by changing the actions of chemicals in your brain.

Chlorpromazine is used to treat psychotic disorders such as schizophrenia or manic-depression, and severe behavioral problems in children. It is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, and acute intermittent porphyria.

Chlorpromazine may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking chlorpromazine?

Chlorpromazine is not for use in psychotic conditions related to dementia. Chlorpromazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use this medication if you are allergic to chlorpromazine, or if you are also using large amounts of alcohol or medicines that make you sleepy.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take chlorpromazine, tell your doctor if you have:

  • liver disease;
  • kidney disease.
  • heart disease or high blood pressure;

  • glaucoma;

  • asthma, emphysema, or other breathing disorders;

  • past or present breast cancer;

  • if you are being treated with chemotherapy for any type of cancer;

  • an enlarged prostate or urination problems,

  • a blockage in your intestines;

  • a seizure disorder or brain tumor; or

  • Parkinson's disease,

Tell your doctor if you will be exposed to extreme heat or to insecticide poisons while you are taking chlorpromazine.

It is not known whether chlorpromazine will harm an unborn baby. Do not take chlorpromazine without first talking to your doctor if you are pregnant. Chlorpromazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medication.
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