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What is the most important information I should know about alfuzosin?

Do not use alfuzosin if you have severe liver disease, or if you are also using ketoconazole (Nizoral), itraconazole (Sporanox), or ritonavir (Norvir). Alfuzosin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Stop using alfuzosin and call your doctor at once if you have new or worsening chest pain, or if you feel light-headed.

Alfuzosin can affect the pupils of your eyes during cataract surgery. If you have cataract surgery during your treatment with alfuzosin, tell the surgeon ahead of time that you are taking this medication. Do not stop using alfuzosin before surgery unless your surgeon tells you to.

What is alfuzosin?

Alfuzosin is in a group of drugs called alpha-adrenergic blockers. Alfuzosin helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Alfuzosin is used to treat benign prostatic hyperplasia (enlarged prostate).

Alfuzosin may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking alfuzosin?

You should not use alfuzosin if you have:

• severe liver disease; or

• if you are also using ketoconazole (Nizoral), itraconazole (Sporanox), or ritonavir (Norvir).

Before taking alfuzosin, tell your doctor if you are allergic to any drugs, or if you have:

• prostate cancer;

• liver disease;
• kidney disease;

• a personal or family history of a heart rhythm disorder called Long QT syndrome;

• angina (chest pain);

• coronary artery disease (such as arteriosclerosis);

• low blood pressure;

• a history of an allergic reaction to alfuzosin;

• if you are taking another alpha-blocker such as terazosin (Hytrin), prazosin (Minipress), doxazosin (Cardura), or guanadrel (Hylorel) for high blood pressure or prostate problems;

• if you are taking an antifungal medicine such as ketoconazole (Nizoral) or itraconazole (Sporanox); or

• if you are taking certain medicines to treat HIV or AIDS.

FDA pregnancy category B. Although alfuzosin is not for use in women, this medication is not expected to be harmful to an unborn baby. If you are a woman using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether alfuzosin passes into breast milk, or if it could harm a nursing baby. If you are a woman using this medication, do not take alfuzosin without telling your doctor if you are breast-feeding a baby.