What is the most important information I should know about alendronate?
Do not take an alendronate tablet if you cannot sit upright or stand for at least 30
minutes. Alendronate can cause serious problems in the stomach or esophagus (the tube that
connects your mouth and stomach). You will need to stay upright for at least 30 minutes after
taking this medication.
Take the alendronate tablet first thing in the morning, at least 30 minutes before you eat or
drink anything or take any other medicine.
Take each dose with a full glass (6 to 8 ounces) of
water. Use only plain water (not
mineral water) when taking an alendronate tablet.
For at least the first 30 minutes after taking an alendronate tablet, do not lie down or
recline; do not eat or drink anything other than plain water; and do not take any other medicines
including vitamins, calcium, or antacids.
Some people using medicines similar to alendronate have developed bone loss in the jaw,
also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling,
numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.
You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been
treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis
of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing
dental problem.
Alendronate is only part of a complete program of treatment that may also include diet
changes, exercise, and taking calcium and vitamin supplements. Follow your diet, medication,
and exercise routines very closely.
What is alendronate?
Alendronate is in the group of medicines called bisphosphonates (bis FOS fo nayts). It
alters the cycle of bone formation and breakdown in the body. Alendronate slows bone loss
while increasing bone mass, which may prevent bone fractures.
Alendronate is used to treat or prevent postmenopausal osteoporosis and steroid-induced
osteoporosis. Alendronate is also used to treat Paget's disease of bone.
Alendronate may also be used for other purposes not listed in this medication guide.
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