• Basic Info
• Top Questions
• Clinical Info
• Interactions

Before taking this medication, tell your doctor if you are using any of the following drugs:

• lithium;

• digoxin (Lanoxin);

• cholestyramine (Prevalite, Questran) or colestipol (Colestid);

• steroids (prednisone and others);

• other blood pressure medications;

• NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others; or

• insulin or diabetes medicine taken by mouth.

This list is not complete and there may be other drugs that can interact with hydrochlorothiazide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

• dry mouth, thirst, nausea, vomiting;

• feeling weak, drowsy, restless, or light-headed;

• fast or uneven heartbeat;

• muscle pain or weakness;

• numbness or tingly feeling;

• a red, blistering, peeling skin rash; or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• diarrhea;

• mild stomach pain;

• constipation; or

• blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.