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Before taking captopril, tell your doctor if you are taking any of the following drugs:

• lithium (Lithobid, Eskalith);

• a potassium supplement such as K-Dur, Klor-Con;

• salt substitutes that contain potassium;

• drugs that can dilate blood vessels, such as alprostadil (Caverject, Edex), nitroglycerin, nitroprusside (Nitropress), nesiritide (Natrecor), minoxidil (Loniten), or isosorbide dinitrate (Imdur, Isordil);

• aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), naproxen (Aleve, Naprosyn), and others; or

• a diuretic (water pill).

If you are using any of these drugs, you may not be able to use captopril or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect captopril. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• feeling light-headed, fainting;

• urinating more or less than usual, or not at all;

• fever, chills, body aches, flu symptoms;

• pale skin, easy bruising or bleeding;

• fast, pounding, or uneven heartbeats;

• chest pain; or

• swelling, rapid weight gain.

Less serious side effects may be more likely to occur, such as:

• cough;

• loss of taste sensation, loss of appetite;

• dizziness, drowsiness, headache;

• sleep problems (insomnia);

• dry mouth, sores in the mouth or on the lips;

• nausea, diarrhea, constipation; or

• mild skin itching or rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.