Trazodone Health Article

Definition

Trazodone is an oral antidepressant. It is sold in the United States under the brand name Desyrel and is also available under its generic name.

Purpose

Trazodone is used to treat depression and to treat the combination of symptoms of anxiety and depression. Like most antidepressants, trazodone has also been used in limited numbers of patients to treat panic disorder, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, enuresis (bed-wetting), eating disorders such as bulimia nervosa, cocaine dependency, and the depressive phase of bipolar (manic-depressive) disorder. It should be noted, however, that trazodone has not received official approval from the United States Food and Drug Administration (FDA) for these secondary uses.

Description

Trazodone acts to change the balance of naturally occurring chemicals in the brain that regulate the transmission of nerve impulses between cells. Its action primarily increases the concentration of norepinephrine and serotonin (both chemicals that stimulate nerve cells) and, to a lesser extent, blocks the action of another brain chemical, acetylcholine. Trazodone is classified as an atypical antidepressant, but it shares many of the properties of tricyclic antidepressants (amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine). It also shares some of the properties of selective serotonin reuptake inhibitor antidepressants (fluoxetine, paroxetine, and sertraline). Trazodone is the most sedating, and least anticholinergic, of all the currently marketed antidepressants.

The therapeutic effects of trazodone, like other antidepressants, appear slowly. Maximum benefit is often not evident for at least two weeks after starting the drug. People taking trazodone should be aware of this and continue taking the drug as directed even if they do not see immediate improvement.

Recommended dosage

As with any antidepressant, trazodone must be carefully adjusted by the physician to produce the desired therapeutic effect. Trazodone is available as 50-mg, 100-mg, and 150-mg film-coated tablets that cannot be divided, and 150-mg and 300-mg oral tablets that can be split. Therapy is usually started at a total of 150 mg per day divided into two or three doses. This dose is increased by 50 mg every three or four days until the desired effects are seen. Daily doses may be increased to a maximum of 400 mg per day in outpatients and up to 600 mg per day in hospitalized patients. In cases of extreme depression, daily doses of up to 800 mg have been used in hospitalized patients. To minimize daytime drowsiness, a major portion of the daily dose can be given at bedtime.