Oligodendroglioma Health Article

Definition

Oligodendrogliomas are a rare form of brain tumors. The brain is made up of many supporting cells that are called glial cells. Any tumor of these glial cells is called a glioma. Oligodendrogliomas are tumors that arise from a type of glial cell called oligodendrocytes. These cells are the specialized cells of the brain that produce the fatty covering of nerve cells (myelin).

Description

Oligodendrogliomas can grow in different parts of the brain, but they are most commonly found in the frontal or temporal lobes of the cerebrum. The frontal lobes are responsible for cognitive thought processes (knowing, thinking, learning, and judging). The temporal lobes are responsible for coordination, speech, hearing, memory, and awareness of time.

There are two types of oligodendroglioma: the well-differentiated tumor, which grows relatively slowly and in a defined shape; and, the anaplastic oligodendroglioma, which grows much more rapidly and does not have a well-defined shape. Anaplastic oligodendrogliomas are much less common than well-differentiated oligodendrogliomas.

More common than either form of pure oligodendroglioma is the mixed glioma, or oligoastrocytoma. These mixed gliomas are a mixture of oligodendroglioma and astrocytoma. An astrocytoma is a tumor that arises from the astrocytes, specialized cells in the brain that regulate the chemical environment of the brain and help to form the blood-brain barrier.

Oligodendrogliomas and mixed gliomas account for approximately 4 to 5% of all primary brain tumors and 10% of all gliomas. A primary brain tumor is a tumor that begins in the brain, as opposed to a secondary (or metastatic) brain tumor, which originates in another organ and spreads (metastasizes) to the brain.

Demographics

Oligodendromas occur in approximately nine in every one million people. Oligodendrogliomas can occur in people of any age, but most occur in middle-aged adults.

Oligodendrogliomas occur with equal frequency in members of all races and ethnic groups. There does not appear to be any relation of oligodendrogliomas to any geographic region. For unknown reasons, men are affected by oligodendrogliomas in higher numbers than women.