Adenoma Health Article

Definition

A benign (noncancerous) tumor that forms from the cells lining the inside or the surface of an organ.

Description

Adenomas arise from cells that are specialized for secretion. These cells, called epithelial cells, are found throughout the body, but only a fraction is designed for secretion. This type of epithelial cell makes up specific organs and structures in the body known as glands. Glands produce sweat, saliva, mucus, milk, digestive juices, hormones, and an array of other substances. Hormone-secreting (endocrine) glands include the thyroid, pituitary, parathyroids, adrenals, and the ovaries and testes. Gland cells that secrete material outward through a duct, such as sweat glands and glands secreting digestive juices into the stomach and intestines, are called exocrine glands. Adenomas can arise from most of the gland cells in the body.

Adenomas result from excessive growth of normal epithelial cells. They arise in much the same way as malignant (cancerous) tumors but do not spread (metastasize) to nearby tissue or other parts of the body. New cells are normally created only when they are needed by the body. When the body does not need new cells and cell division continues, a mass or tumor is formed.

Tumors found on some glands are more likely to be adenomas than malignant tumors (carcinomas), including adrenal tumors, pituitary tumors, and salivary gland tumors. The adrenal tumor known as pheochromocytoma is benign in 90% of reported cases. The gastrinomas associated with Zollinger-Ellison syndrome are benign in 50% of patients with this condition. Adenomas are also associated with Cushing's syndrome, a disorder caused by excess levels of a hormone secreted by the adrenal glands. Although most cases are caused by a dysfunctional pituitary gland, 20-25% are due to adrenal adenomas.

The occurrence of an adenoma rarely indicates an increased chance for the later development of a carcinoma. However, colon cancer and rectal cancer are thought to arise from adenomas, and one type of lung adenoma—called a bronchial adenoma—can potentially develop into lung cancer.

Most adenomas affect the normal functioning of the organ or gland in which it arises, although some have no effect. Many secrete hormones, leading to elevated hormone levels in the blood and causing uncomfortable and sometimes life-threatening conditions.