Pancreatic islet cell tumor Health Article

Definition

A pancreatic islet cell tumor is an uncommon tumor of the pancreas that arises from a type of cell called the islet cell in the pancreas.

Alternative Names

Islet cell tumors; Islet of Langerhans tumor; Neuroendocrine tumors

Causes, incidence, and risk factors

In the normal pancreas, cells called islet cells produce hormones that regulate a variety of bodily functions, such as blood sugar level and the production of stomach acid.

Tumors that arise from islet cells of the pancreas can also produce a variety of hormones, though some do not.

Although islet cells produce many different hormones, most tumors release only one hormone that leads to specific symptoms. Pancreatic islet cell tumors can be noncancerous (benign) or cancerous (malignant).

Islet cell tumors include:

• Gastrinomas (Zollinger-Ellison syndrome)
• Glucagonomas
• Insulinomas

A family history of multiple endocrine neoplasia, type I (MEN I) is a risk factor for islet cell tumors.

Symptoms

Symptoms are caused by the hormone the tumor is producing. For example, an insulinoma may produce too much insulin, leading to very low blood sugar levels.

Symptoms can include:

• Abdominal pain
• Anxiety
• Behavior changes
• Clouding of vision
• Confusion
• Convulsions
• Diarrhea
• Dizziness
• Headache
• Hunger
• Inflamed mouth and tongue
• Loss of consciousness
• Peptic ulcer pain
• Rapid heart rate
• Skin rash that moves on the face, abdomen, buttocks, or feet
  • May be crusty and scaly
  • May have raised sores filled with clear fluid or pus
• Sweating
• Tremor
• Vomiting blood
• Weight gain (unintentional)
• Weight loss

Signs and tests

Tests may vary depending upon the symptoms. The following tests may be performed:

• Abdominal CT scan
• Abdominal ultrasound
• Endoscopic ultrasound
• Fasting glucose level
• Gastrin level
• Gucose tolerance test
• Intraductal endoscopic ultrasound
• MRI of abdomen
• Sampling the vein drainage of segments of the pancreas
• Secretin stimulation test for pancreas
• Serum glucagon level
• Serum insulin C-peptide
• Serum insulin level

Occasionally, surgery is needed to diagnose and treat this condition. During this procedure, the surgeon feels the pancreas and may use ultrasound probes.